Her death was announced by a spokeswoman, Holly Byrd, who said in an email late Sunday that Ms. Hetse had “peacefully been removed from life support.” Ms Heche was seriously injured on August 5 when a Mini Cooper she was driving crashed into a two-storey house in the Mar Vista neighborhood of Los Angeles, sparking a fire that took firefighters more than an hour to put out. Ms Heche, who was alone in the car, suffered burns and severe anoxic brain damage, caused by a lack of oxygen to the brain. A Los Angeles police spokesman said the department continues to investigate whether drug use was a factor in the crash. A statement released by her family on Thursday evening said Ms Heche remained in a coma at the Grossman Burn Center at West Hills Hospital in Los Angeles. “It has long been her choice to donate her organs and she is being kept on life support to see if any are viable,” the statement said. On Friday, a spokesman said Ms Heche had been declared brain dead on Thursday night. Mrs. Heche was a soap opera star before she became known to movie audiences. In the late 1980s, right after graduating from high school, she joined the cast of the daytime drama Another World, where she played the good and bad twins Vicky Hudson and Marley Love. She won a Daytime Emmy Award in 1991 for Outstanding Younger Actress in a Drama Series. By the mid-1990s, he was a rising star in Hollywood. Played Catherine Keener’s best friend in “Walking and Talking” (1996). Johnny Depp’s wife in “Donnie Brasco” (1997). Assistant to the President in the political satire “Wag the Dog” (1997), with Dustin Hoffman and Robert De Niro. and a fashion magazine editor who lands on a South Sea island in a plane piloted by Harrison Ford in “Six Days, Seven Nights” (1998). “Romantic comedies don’t get more formulaic than this Valentine, but they don’t get much more enjoyable either,” wrote Rita Kempley in her Washington Post review of “Six Days, Seven Nights.” “The same goes for Hatche and Ford as warring opposites who come together during this tropical adventure.” Ms. Heche began a relationship with Ms. DeGeneres in 1997, at a time when same-sex relationships in Hollywood were not fully accepted. The relationship became widely known in April of that year when they appeared, hand in hand, at the annual White House Correspondents’ Dinner in Washington. A few days later, Ms. DeGeneres’ character on her sitcom, “Ellen,” came out as gay. Ms. Heche’s decision to reveal that she was in a lesbian relationship, the New York Times wrote, “confronted Hollywood with an extremely delicate problem: how to deal with a gay actress whose career was built on playing heterosexual roles.” After that relationship ended, Ms. Heche married and later divorced a man, Coleman Laffoon, with whom she had a son, Homer. She also had a son, Atlas Heche Tupper, from her relationship with actor James Tupper. Complete information on her survivors was not immediately available. Ms. Heche told the New York Post in 2021 that she had been “blacklisted” in Hollywood because of her relationship with Ms. DeGeneres. “I haven’t done studio photography in 10 years,” he is quoted as saying. “I walked away from a $10 million deal and didn’t see the light of day in a studio picture.” After starring in “Six Days, Seven Nights” and Gus Van Sant’s 1998 remake of Alfred Hitchcock’s “Psycho” as Marion Crane, the role originally played by Janet Leigh, leading film roles gave way to guest appearances on TV shows such as ‘Ally McBeal’ and ‘Nip/Tuck’. He also starred in the short-lived sitcom “Men in Trees,” had recurring roles on “Everwood” and “Chicago PD,” and landed a featured role on the HBO series “Hung,” which starred Thomas Jane as a male prostitute. He appeared on Broadway in Proof from 2002 until it closed in 2003, then in the 2004 revival of Twentieth Century, the 1932 comedy about a Broadway producer (Alec Baldwin) who, as a passenger on the Twentieth Century Limited train, he meets a former discovery, Lily Garland (Ms. Hetse), who has become a Hollywood star. The role earned Ms. Heche a Tony Award nomination for Best Performance by an Actress in a Play. In his review for The Times, Ben Brantley wrote: “Her attitude melts between serpentine allure and street-fighter aggression, her voice shifts between velvet and super-club vinyl, Ms. Heche summons a whole collection of sirens from studio. from the Depression era: Jean Harlow, the pre-mummified Joan Crawford and, yes, Carole Lombard, who famously played Lily in Howard Hawks’s Twentieth Century screen version. In 2004, Ms. Heche was nominated for a Primetime Emmy for Outstanding Supporting Actress in a Miniseries or a Movie for her performance in “Gracie’s Choice,” a TV movie about a teenage girl dealing with raising her half-siblings after they become addicted from drugs. the mother is sent to prison. He most recently appeared in the films “The Vanished” (2020), a psychological thriller, and “13 Minutes” (2021), which focuses on a tornado, as well as several episodes of the courtroom drama “All Rise”. Anne Celeste Heche was born on May 25, 1969, in Aurora, Ohio, to Nancy and Donald Heche. Her father was an evangelical Christian and, as it turned out, a closeted gay man. Her first role was in a New Jersey dinner theater production of “The Music Man,” which paid her $100 a week. In 1983, after her father died of AIDS, her mother became a Christian therapist and lectured on behalf of James Dobson’s Focus on the Family organization about “overcoming” homosexuality. Ms. Heche wrote in her 2001 memoir, “Call Me Crazy,” about her father’s sexual abuse and her mother’s denial of that abuse. She said that when she called her mother after years of therapy to confront her, her mother ended the conversation by saying, “Jesus loves you, Anna,” before hanging up. “People wonder why I’m so forthcoming with the truths of what happened in my life,” Ms. Heche said in a 2009 Times interview. badly, gave birth to a child of truth and love”. In 2018, she said she was fired from a job at Miramax after she refused to give oral sex to Harvey Weinstein, the disgraced movie mogul who founded the company with his brother, Bob, and who has been accused of sexual assault by dozens of women. . He was convicted of two felony sex crimes in 2020 and is serving a 23-year prison sentence. “If I hadn’t been sexually abused as a child, I don’t know if I would have had the strength to stand up to Harvey — and a lot of others, by the way,” she said on the “Supposedly … With Theo Von & Matthew Cole Weiss” podcast. “It wasn’t just Harvey, and I’ll say that.” Vimal Patel contributed reporting.